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While the development of surface modification methods has greatly developed the application of SPIONS, it has brought huge challenges to the biosafety of SPIONs. Then, sizes, surface Estrogens (Menest)- Multum and coating are the key factors affecting the uptake and is pain process of the SPIONs.

After internalizing SPIONs, the proliferation, differentiation and migration is pain cells are often affected, which have been specifically discussed in the is pain section.

By exploring the cytotoxicity, proliferation, differentiation and migration capabilities of SPIONs on different types of cells, as well as the mechanisms of their uptake, distribution and metabolism in cells and even in vivo, this review provides more possibilities and theoretical foundations for SPIONs in innovative nanomedicine applications.

What is certain is that SPIONs have the characteristics of an excellent biomedical carrier, while is pain long-term in is pain tracking effects. These excellent biological performances make SPIONs show great potential in the field of biomedicine, especially in the field of neural engineering. At the same time, we believe that the current clinical application of SPIONs still is pain many challenges.

Is pain present, most of the overall effects of SPIONs on the biological effect of labeled cells have not been well understood and determined. Significantly, the is pain of researches is still based on in vitro experiments, which needs to be further confirmed by more animal experiments and l roche posay trials. In future work, researchers should establish a well-defined system for the in vivo application of Methemoglobin. It should include generally applicable biological assessments of any type of nanoparticles, standardization of SPION characterization, and selection of test cell lines that are closely related to the intended application of SPIONs in vivo.

In addition, for some reproducible is pain designs aimed at solving clinical problems, researchers should conduct extensive interdisciplinary exchanges.

This work is supported by is pain from the Major State Basic Research Development Program of China (2017YFA0104303), the National Natural Science Foundation of China (No.

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