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The laboratory also roche france genes involved in development Demecarium (Humorsol)- FDA lymphatic vasculature. Susan E QuagginThe major research focus is roche france the genetic and molecular pathways that establish and maintain complex capillary structures, particularly those forming roche france renal glomerular filtration barrier.

Gregory W SchwartzAssociate Professor of Ophthalmology, Neuroscience and Weinberg College of Arts and SciencesThe research program in computational neuroscience and systems neurophysiology relates to our understanding of how ganglion cells respond to various light stimuli. In addition, the laboratory studies the visual processing circuits in the inner synaptic layer of the retina. Mark Segraves, PhDThe laboratory uses the eye movement system as a model for how the brain of primates, including man, controls roche france variety roche france movements.

Basic research focus novel methods for ocular drug delivery and prevention of fibrosis after incisional glaucoma surgery. For more information, visit the faculty profile for Yongling Zhu, PhD. The pattern of gene expression in eukaryotic cells is strongly influenced by interactions with neighboring cells.

When cell-cell interactions are perturbed, changes in cellular gene activity roche france often observed. Major goals of our current research are to elucidate the molecular mechanisms responsible for transcriptional activation and roche france determine the extracellular inductive signal and the signal transduction pathways involved. We are particularly interested in the role of taurine and glutamate transporters in retinal ischemia and glutamate neurotoxicity.

We have already cloned and characterized GABA, taurine and glutamate transporters from retina. For roche france information visit Dr. Failure to form the cardiovascular system often leads to embryonic lethality and roche france disorders of the cardiovascular system are quite common in humans. The causes and underlying developmental mechanisms of these disorders, however, are roche france understood.

A particular emphasis in our laboratory has recently been the study of cardiovascular signaling pathways and transcriptional regulation in physiological and pathological settings using mice as animal models, as well as embryonic stem (ES) cells as an in vitro differentiation system.

The ultimate goal of our research is to provide new insights into the mechanisms that lead to the development of therapeutic strategies designed to treat roche france relevant conditions of pathological neovascularization. For more information, visit the faculty profile for Tsutomu Kume, PhD. Austin Culver MD Candidate 312-503-3008Anees Roche france Assistant Professor 312-503-0554Christine Elizabeth Kamide Senior Research Technologist 312-503-1446Erin Lambers PhD Candidate 312-503-5652Ting Liu Senior Research Technologist 312-503-3008Jonathon Misch Research Technologist 312-503-6153Our lab focuses on the basic biology of vascular tyrosine KCL in NS (Potassium Chloride in Sodium Chloride Injection)- FDA signaling in development and diseases of the blood and lymphatic vasculature.

Our projects include uncovering the molecular mechanisms of diabetic vascular complications, thrombotic microangiopathy, glomerular diseases and glaucoma. Utilizing a combination of mouse genetic, cell biologic and proteomic approaches, we have identified key roles for Roche france and VEGF signaling in these diseases.

Members of the lab are developing novel therapeutic agents that target these pathways. For more information, please see roche france faculty profile of Susan Quaggin, MDSee Roche france. In the mammalian retina, the responses of roche france cone photoreceptor inputs are temporally uniform when stimulated with equivalent lights.

However, the retinal ganglion cell outputs can be grouped into 30 to 35 different classes based on roche france temporal properties of their light responses, morphology and central targets. Our goal is to characterize the processing in the parallel retinal networks that leads to these roche france responses.

In the outer retina, we record from cone and bipolar cell pairs; whereas, in the inner retina, our goal is to optogenetically stimulate bipolar cells and record from identified postsynaptic ganglion cells.

For more information, visit the faculty profile for Steven H. The Lavker laboratory focuses on the biology of epithelial stem cells and the roles of microRNAs (miRNAs) in regulating epithelial homeostasis. In collaboration with Tung-Tien Sun (NYU Medical School), the lab identified and characterized stem cells of the epidermis, hair follicle and corneal epithelium.

We have demonstrated that the hair follicle stem cells (located in the bulge region of roche france follicle) are pluripotent; capable of forming the hair shaft as well as roche france epidermis.

Collectively, these studies have been of major importance for their implications regarding tissue regeneration, hair follicle growth, and carcinogenesis. Initial investigations on microRNAs (miRNAs) focused on corneal epithelial-preferred roche france. Specifically, miR-205 undergoes a unique form of regulation through an interaction with the corneal-preferred miR-184 to maintain SHIP2 levels.

SHIP2, a lipid phosphatase, is a target roche france miR-205, which enhances keratinocyte survival through PI3K-Akt signaling.

Roche france miRNA also positively regulates keratinocyte migration by altering F-actin organization and decreasing cell-substrate adhesion. Recently, the lab has focused on miR-31, which targets factor inhibiting hypoxia-inducible factor-1 (FIH-1). FIH-1 impairs epithelial differentiation via attenuation of Notch signaling. This provides a rationale for development of treatment regimens in patients with diseases affecting abnormal epithelial differentiation (e.

We have also demonstrated that miR-31 targets FIH-1 to positively regulate corneal epithelial glycogen metabolism, which roche france in the accumulation of glycogen. Increased glucose in the form of glycogen may roche france a mechanism by which the corneal epithelium is roche france to withstand periods of hypoxia during eyelid closure or extended contact lens wear. Most recently, the laboratory has defined the microRNA expression patterns of the stem cell-enriched limbal basal cells and has begun to identify targets that are unique to the limbal epithelium.

This should lead to an understanding of how miRNAs regulate epithelial stem cells. Robert Lavker, PhD, Impact factor medical research archives Peng, PhDContact the Lavker Lab at 312-503-2043 or roche france us on campus in the Montgomery Ward Building, 303 E.

Chicago Avenue, Ward 9-120, Chicago, Illinois, 60611. Lavker, PhD, Han Peng, PhDResearch roche france the Longnecker laboratory focuses on herpes simplex virus (HSV) and Epstein-Barr virus (EBV).

These viruses typically cause self-limiting disease within the human population but both can be associated with serious complications. EBV is associated with variety of hematopoietic cancers such as African Burkitt lymphoma, Hodgkin Lymphoma and adult T-cell leukemia.

EBV-associated lymphoproliferative disease roche france in individuals with congenital or acquired cellular immune deficiencies. The two notable epithelial diseases associated with EBV infection are nasopharyngeal cancer and oral hairy leukoplakia.

Similar to EBV, HSV latent infections roche france very common in humans. HSV typically does not cause severe disease but is associated with localized mucocutaneous lesions, but in some cases can cause meningitis and encephalitis. The Longnecker laboratory focuses on several aspects of EBV and HSV replication and pathogenesis.

First, the molecular basis EBV transformation roche france how it relates to cancer is being investigated. Second, the laboratory is investigating herpesvirus latency in the human host and pathogenesis associated with infections in humans. In this regard, the laboratory is developing animal models for EBV and HSV infections.

Ultimately, studies by the Longnecker laboratory may provide insight for the development of novel therapeutics for the treatment of herpesvirus infections in humans and better understanding of the herpesvirus life cycle in the human hostFor lab information and more, see Dr. Longnecker at 312-503-0467 or the lab at 312-503-0468 or 312-503-9783. Jia Chen, Qing Fan, Kamonwan "Pear" Fish, Masato IkedaSarah Connolly, Michelle Swanson-MungersonCooper Hayes, Daniel Giraldo Perez, Seo Jin ParkSarah Kopp, Rachel Riccio, Samantha Schaller, Nanette SusmarskiRetinoblastoma, the most common pediatric cancer of the eye, is a devastating and sometimes fatal pediatric cancer.

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